Frozen Section Biopsy for Breast Cancer

Medically reviewed by: Dr. Jay R. Anam

Frozen Section Biopsy for Breast Cancer

Overview

Biopsies extract a small portion of the mass where doctors expect tumours after examining it under a microscope. It helps to identify the chances of cancer, infection or any other disease.

So if the oncologist suspects someone of cancer, a piece of tissue is taken or extracted from the patient’s body. A biopsy of the tissue is done to check whether the cancer is malignant or benign. 

In the case of breast cancer, frozen section biopsy is a very common procedure to check whether the tissue is malignant or benign (cancerous OR non-cancerous). It is also called an intra-operative frozen section.

How is frozen section biopsy performed?

It is a process in which tissue is removed from the suspected body part and is taken to a laboratory. The pathologist freezes the tissue in a cryostat machine first and then begins the test. The tissue is cut with the help of a microtone and placed at a -25-degree centigrade temperature.

A biopsy of the breast tissues through a frozen section can give accurate results and has advantages.

Why is frozen section biopsy important?

A frozen section biopsy is important because it is trusted by most pathologists and oncologists for determining the extent of cancer. A frozen section biopsy is very quick and saves a lot of time in the procedure. 

  • It saves the need for another operation, as the surgeon can obtain the tissues quickly. This process requires little tissue for a correct diagnosis.

  • Most surgeons rely on this method as the treatment can be done quickly. If the tissue is found cancerous, then the breasts can be removed or treated as per the oncologist.

  • If the tissue is found to be benign (non-cancerous), there is no need to proceed further.

  • A frozen section biopsy takes very little time for the results to come. It takes less than 20 minutes as compared to any other procedure.

  • Frozen section can reduce re- surgery rates in breast conservation procedures done for breast cancer.

Breast core biopsy showing infiltrating ductal carcinoma (frozen section, ×100).

How accurate is frozen section biopsy?

    The frozen section biopsy was introduced in 1905. Since then, there has been enough innovation in the technique. The modern frozen section biopsies are known to produce accurate results. However, there have been enough discussions and debates regarding the accuracy of the biopsies. In the case of the ovary, the tumours that were visible or collected gave accurate results in the frozen section biopsy test. 

    A test conducted among 4436 breast biopsies in the last 5 years shows that these results are accurate. Although there were a few cases of false-negative the majority of cases were accurate. Frozen section cases were accurate in almost 92.7% of the total cases. The remaining 7% of the cases showed incorrect results.

    However, the report also shows that borderline tumours do not get easily caught by the frozen section biopsy. This is indeed a matter of concern as borderline cancer will not be detected.

    However, this is not the only method by which the suspected tissue will be tested. Oncologists with the help of pathologists, apply several other methods also to check the tissue.

    Read Also:- How Much Does It Cost for Breast Cancer Treatment in India

    Does the world still rely upon frozen section biopsy for breast cancer?

    Yes, medical practitioners still rely upon frozen section biopsy to get the best results. When a breast conservation surgery is done the specimen is sent for a frozen section to check the margins. Surgery is successful if the margins of a specimen are free of any cancer cells. 

    Also, for sentinel node biopsy intraoperative frozen section is very important, so as to complete the entire surgery in one go. In some countries where a frozen section is not available, patients need to undergo second surgery once a histopathology report is received after a week.

    Read Also: Breast Biopsy

     

    Frozen Section biopsy for breast cancer

    Why do doctors choose to go through frozen section biopsy?

    There are a couple of reasons why doctors choose the process of frozen section biopsy. Some of them are as follows:

    • The doctors may find this process suitable for accurate diagnosis as the process helps to get an additional sample to avoid a second operation.
    • The pathologist and the surgeon can work together for the proper treatment of the patient.
    • The process helps to collect an adequate tissue sample for in-depth scientific research. 
    • It helps ensure the doctors that the whole mass, along with safe margin, is removed. 

    Conclusion

    Frozen section biopsy for breast cancer is a great technique to check for the tissues, whether they are benign or malignant. This technique involves no pain or slight pain at times in extracting the tissues.

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      About Author
      Dr. Jay Rashmi Anam

      Surgical Oncologists

      15+

      Year Of Experience

      Dr. Jay Anam is one of the best surgical oncologists & breast cancer specialist in Mumbai.

      Dr. Jay Anam has Completed his M.Ch. Surgical Oncology training from Tata Memorial Centre. He did his Fellowship in Breast Oncology from Centre Oscar Lambret, Lille, France.

      As a breast cancer specialist, he believes in world-class cancer care for all patients.

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      Facing breast cancer surgery is a brave step, and we know the recovery process may feel overwhelming at times. One aspect of recovery many patients encounter is managing surgical drains.

      While these medical devices play a crucial role in your healing, they can be intimidating at first. But don’t worry. With the right knowledge and tools, you can manage them confidently and focus on feeling better.

      This guide is here to walk patients and caregivers through every step of drain care—from the basics to troubleshooting to emotional support. By the end, you'll feel prepared to tackle this part of your recovery with ease.

      How to Reduce Drainage After Mastectomy?
      Author
      dr-jay-anam-favicon

      Dr. Jay Anam

      Breast Cancer Surgeon and Oncoplasty specialist in Mumbai

      Introduction

      Why are surgical drains important after breast cancer surgery? These small, plastic tubes help remove excess fluids that can build up in your body as you heal. Getting rid of this fluid reduces swelling, prevents complications like infections, and helps your body recover faster.

      We’ll cover everything you need to know, including how to empty and clean your drains, spot signs of infection, manage discomfort, and return to daily life with confidence.

      Understanding Surgical Drains

      To start, it’s helpful to understand what surgical drains are and why they’re used.

      What Are Surgical Drains and Why Are They Necessary?

      After surgery, your body produces fluid as part of its natural healing process. Sometimes, this fluid needs help draining so it won’t pool under the skin. That's where surgical drains come in.

      Types of Drains

      There are a few kinds of surgical drains commonly used:

      • Jackson-Pratt (JP) drain – Often shaped like a small bulb, this popular option collects fluid that you can measure and empty.
      • Hemovac drain – A slightly larger round container, often used for higher drainage needs.

      Your surgeon will determine the best type for you based on your surgery.

      How Long Will They Stay in Place?

      The timeline varies. Most patients have their drains for 7 to 14 days, but it depends on how much fluid they produce. Don’t worry; your doctor will remove them once output slows down.

      Step-by-Step Drain Care Guide

      Drain care is manageable if broken down into steps. Let's cover the essentials.

      How to Empty the Drain Properly

      1. Wash your hands thoroughly with soap before touching the drain.
      2. Unplug the bulb or container, holding it upright.
      3. Carefully pour the fluid into a measuring cup.
      4. Record the amount and time in a log to share with your doctor.
      5. Squeeze the bulb to reset the suction before plugging it back in.

      💡 Tip: Empty the drains 2-3 times a day, or whenever they’re about half full.

      Cleaning & Infection Prevention

      • Gently clean around the drain site with soap and water or antibacterial wipes. Avoid tugging or rubbing the area.
      • Watch for signs of infection, such as:
        • Redness or swelling around the site
        • Fever above 100.4°F
        • Foul odor or colored drainage

      If you notice these, call your doctor.

      Best Sleeping Positions

      Finding a comfortable position can be tricky. Try:

      • Sleeping on your back with pillows under your arms for support.
      • If you’re a side sleeper, place a small cushion around the drains for padding and avoid putting pressure on them.

      💡 Tip: A drain-friendly post-surgery pillow with built-in pockets can make rest easier.

      Showering & Hygiene Tips

      Ask your surgeon if showers are allowed. If so:

      • Cover your drains with a waterproof dressing or use a surgical drain belt.
      • Limit water exposure to avoid infections.

      If showering isn’t an option, stick to sponge baths until your doctor gives the green light.

      Recognizing and Managing Complications

      Sometimes, issues arise. Here’s what to keep an eye on:

      When to Call Your Doctor

      • Drainage suddenly increases or stops altogether
      • Severe pain or swelling
      • Fever or signs of infection

      Dealing with a Clogged Drain

      A frequent issue is a clogged drain. If you notice reduced suction:

      1. Milk the tube by gently squeezing it to dislodge the blockage.
      2. If this doesn’t help, notify your healthcare provider promptly.

      Signs of Seroma (Fluid Buildup)

      Once drains are removed, some patients develop a seroma. Symptoms include swelling, tenderness, or a feeling of liquid under the skin. While many seromas go away on their own, consult your doctor for advice.

      Pain & Discomfort Management

      • Pain is part of recovery, but you don’t have to suffer unnecessarily.

        Medication vs. Non-Drug Relief

        • Use prescribed painkillers as directed.
        • Non-medical options, like a cold compress or heating pad (with your doctor’s approval), can help with aches and stiffness.

        Gentle Exercises

        Simple arm stretches or shoulder rolls can prevent tightness, but avoid anything strenuous. A physical therapist can provide guidance.

        Relaxation Techniques

        Practice deep breathing or try mindfulness exercises to cope with discomfort.

      Diet & Nutrition for Faster Healing

      Fueling your body helps tissues heal faster. Focus on:

      • Protein-rich foods, like lean meats, tofu, beans, and eggs.
      • Anti-inflammatory options, like berries, leafy greens, and nuts.
      • Drink plenty of water every day.
      • Consider supplements, like zinc or vitamin C, but check with your doctor first.

      Physical Activity & Movement Guidelines

      Movement helps, but balance is key:

      • Begin with light stretches or short walks to prevent stiffness.
      • Avoid lifting anything heavier than a few pounds in the first week.
      • Your doctor will guide you on when you can resume driving or house chores.

      💡 Tip: Use a supportive bra to minimize any strain during recovery.

      Emotional & Psychological Support

      Caring for drains can feel isolating. It’s okay to have mixed emotions.

      Coping with Anxiety

      Deep breathing, journaling, or talking to a friend can help manage stress.

      Find Support Groups

      Connect with others who’ve been in your shoes. Online breast cancer recovery forums or local groups can make you feel less alone.

      Mental Health Resources

      Don’t hesitate to reach out to a counselor or therapist to process emotions during your recovery.

      Emotional & Psychological Support

      Caring for drains can feel isolating. It’s okay to have mixed emotions.

      Coping with Anxiety

      Deep breathing, journaling, or talking to a friend can help manage stress.

      Find Support Groups

      Connect with others who’ve been in your shoes. Online breast cancer recovery forums or local groups can make you feel less alone.

      Mental Health Resources

      Don’t hesitate to reach out to a counselor or therapist to process emotions during your recovery.